Evaluación de la eficacia terapéutica de quitosano enriquecido con aloe vera y sangre de drago para la cicatrización de quemaduras superficiales

Abstract

This research describes the design and functional analysis of a hydrogel formulated from chitosan, Aloe vera, and dragon’s blood (Croton lechleri), aimed at optimizing the healing process of superficial burns. The proposed formulation represents an accessible and biocompatible alternative, as the combination of these compounds is based on their moisturizing, anti-inflammatory, antioxidant, and regenerative properties. When integrated into a hydrocolloid matrix, these characteristics allow the development of a system designed to interact favorably with injured tissue. The study addresses limitations associated with conventional burn management, such as moisture loss, susceptibility to infection, and delayed re-epithelialization. The hydrocolloid system seeks to counteract these challenges through a polymeric matrix capable of maintaining a moist microenvironment, modulating the inflammatory response, and providing a protective barrier against bacterial colonization. The hydrogel development process includes material selection, preparation of active compounds, and formulation of different combinations with controlled compositional variations. Physical parameters such as stability, viscosity, and moisture retention capacity were also considered to ensure appropriate application over damaged tissue surfaces. The proposed formulation is intended to provide an accessible alternative with potential application in settings where specialized therapeutic resources are limited. Its scientific basis and reliance on natural compounds expand current therapeutic options and support the implementation of low-cost technologies in the field of skin health.