Evaluación de una formulación cosmética con potencial actividad antioxidante y efecto hidratante a base del extracto de malva sylvestris L.

Abstract

Today, skin diseases are increasingly concurrent, caused by various factors, and consumers are looking for new trends in cosmetic products, especially natural cosmetics, which contain natural assets, considering that biodiversity in the country is an important source of bioactive compounds, it is a promising opportunity to be present in skin care formulations as they have dermatological properties that help maintain or restore cutaneous homeostasis, delay aging, maintain skin elasticity and hydration level. Malva sylvestris L. is a cosmopolitan species, with a high therapeutic potential, traditionally used for its potent anti-inflammatory, antioxidant, anticancer, anti ulcerogenic activity and allows to maintain the integrity of the skin. Therefore, in the present study we sought to evaluate the antioxidant activity in vitro and moisturizing effect in vivo of a cosmetic formulation based on the aqueous extract of the species. The concentration of the active substance for the cosmetic formulation was defined according to the sensory preference of the product by a hedonic test; a primary irritability test determined whether the product causes irritation when applied to the skin; The antioxidant capacity in vitro was evaluated with the spectrophotometric technique of the radical DPPH (2.2-diphenyl-1-picrilhydrazyl), expressing the results by means of inhibitory concentration values (IC50); the in vivo moisturizing capacity of the cream was determined at 30, 60, 120 minutes and 7 days after application with the aid of a Corneometer CM825 dermatological analyzer. The concentration of the extract with better acceptance was 1% and additional was evaluated a formulation with mucilage to 3%, none of the formulations applied caused immediate irritation so they were considered suitable for evaluation; The Página 16 de 95 antioxidant capacity in vitro was evaluated with the spectrophotometric technique of the radical DPPH (2.2-diphenyl-1-picrilhydrazyl), expressing the results by means of inhibitory concentration values (IC50); of 339.66 µg/ml and 2266.54 µg/ml respectively. The moisturizing capacity showed significant differences between the cream with mucilage and the cream with extract. Due to the values obtained in this study in terms of irritability, skin hydration and antioxidant action indicate that Malva sylvestris L. can be considered as a promising option to be incorporated in cosmetic formulations because of the multiple benefits that are demonstrated in this study.