Diseño de un sistema de calefacción, ventilación y aire acondicionado basado en las buenas prácticas de manufactura para la producción de sólidos en un laboratorio farmacéutico

Abstract

The purpose of this degree project is to design a heating, ventilation and air conditioning (HVAC) system for a new solids production area in a pharmaceutical laboratory. This area did not have a system that would guarantee the environmental conditions necessary to operate under Good Manufacturing Practices (GMP), so an integral design was proposed to enable its efficient operation in accordance with regulatory standards. The methodology applied included the gathering of technical information of the area, thermal load calculations, determination of air flow rates per zone and the selection of main equipment such as the Air Handling Unit (AHU), fans, dust collectors and grilles. Factors such as the volume of each space, type of activity, number of people and electrical equipment allowed us to calculate the specific ventilation requirements for each room. The HVAC system design included supply, return and exhaust ducts, applying international standard criteria for sizing spans, velocities and connections, ensuring uniform air distribution. 2D technical drawings and P&ID diagrams representing the physical and logical layout of the system were generated. Finally, a preventive and corrective maintenance plan was developed that includes frequencies, activities, control formats and KPIs to ensure the continuous operation of the system. Overall, this proposal provides a complete technical purpose for ensuring air quality, personnel safety and regulatory compliance in the production of pharmaceutical solids.