Evaluación de la presencia de inmunidad humoral específica contra SARS-COV2 causante del COVID-19, en mujeres de la UPS sede Quito en edades superiores a 31 años, posterior al proceso de vacunación

Abstract

SARS-CoV-2 has infected over 100 million people worldwide, causing a cascade of consequences in the economic and social integrity of all countries, making it necessary for population immunization through vaccines, which help the immune system acquire resistance to virus infection. Therefore, this study aims to evaluate specific humoral immunity against SARS-CoV-2 in women aged 31 years and older at UPS Quito after the vaccination process through capillary blood sampling and to qualify them. The statistical evaluation was carried out in Infostat and determined the correlation between the immune response and the variables of vaccines, the number of doses obtained, types of vaccination, time ranges between the last application and the sampling, and the presence of pre-and post-vaccination infections. The existing correlations were reported between immune Response vs Number of doses administered and Presence or not of previous Contagions variables, with p-values of 0.0276 and 0.0127, respectively, two less than α of 0. 05 accepting the alternative hypothesis (variables depend on each other), which concludes that at the time of the booster vaccines, the immunity index increases significantly, and after the administration of the first dose, the presence of IgG rises in people who were infected. On the contrary, people who were not infected presented a low titration of antibodies.