Análisis bioinformático de la convergencia de genes en cáncer y regeneración de tejidos, un dilema en la salud.

Abstract

Modern Biomedicine has focused studies on pathologies related to cancer and wound healing. These two processes share similar cellular and metabolic mechanisms, which has shown that they have a similar genetic participation. However, the genes that are associated with the two processes have not been well reported or characterized. The present study seeks to analyze with bioinformatics programs the convergence of genes in cancer and tissue regeneration with its implication in health. The analysis began with a set of 393 genes obtained from the Genetic Ontology Navigator of the Jackson Laboratory, which participate in healing. To determine the relevance in healing processes, the expression of these genes was analyzed in PDX models, obtaining 66 genes with high expression and 71 genes with low expression. To identify the characteristic genes for cancer, the Catalog of Somatic Mutations in Cancer (COSMIC) was used, obtaining 20 distinctive genes in cancer. Finally, the Hallmark parameters of these genes were compared with the characteristic healing processes, reaching a group of 7 main genes EGFR, EZH2, HIF1A, HRAS, KDR, MTOR and PTEN. For medical implication, the enrichment analysis using g: Profiler of the 7 genes made it possible to identify the PI3K-AKT signaling pathway as the most significant and which is currently a focus of research in cancer and a possible healing enhancer.